Special article


Current challenges in handling genetic data

By Felix Gutzwiller and Patricia R. Blank− In recent years the opportunities for collecting individual genetic data have expanded dramatically. Technological advances in high-throughput sequencing … [Read More...]

Review articles


The advent of biosimilars: challenges and risks

Biosimilars represent a new class of medicinal products that will have significant impact on clinical use. They are identical on a amino acid sequence level to existing reference biopharmaceutical products. However, they may exhibit differences on a … [read more ...]

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The role of teriparatide in sequential and combination therapy of osteoporosis

Treatment of osteoporosis with antiresorptive agents cannot fully and rapidly restore bone mass and structure that has been lost because of increased remodelling. However, recombinant human parathyroid analogues, such teriparatide, do increase the … [read more ...]

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Medical intelligence

Clostridium difficile

Molecular epidemiology of Clostridium difficile for clinical practice

By Sarah Tschudin-Sutter − During the last decade, the world has witnessed numerous outbreaks of Clostridium difficile infections in healthcare settings. Increasing incidence rates of Clostridium difficile infections have been mainly attributed to … [read more ...]

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Current opinion


Novel concepts in the epidemiology, diagnosis and prevention of childhood tuberculosis

By Nicole Ritz  and Nigel Curtis− A number of major advances have been made in the understanding of the epidemiology, diagnosis and protection of childhood tuberculosis in the last few years. This has led to childhood tuberculosis being lifted out … [read more...]

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Original articles

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Diabetes management from the patients’ perspective

By Anja Frei, Oliver Senn, Felix Huber, et al. − Patients with chronic illnesses benefit from care following the concept of the Chronic Care Model. This paper adds the patients’ perspective of diabetes care comparing traditional primary care … [read more ...]

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The outcome of community-acquired pneumonia in patients with chronic lung disease

By Frank Dusemund, Joannis Chronis, Florent Baty, et al. − The impact of pre-existing chronic lung diseases on disease-related complications and outcome in CAP is controversial. Our results indicate a lower incidence of the composite complications … [read more ...]

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Excessive alcohol consumption in young men: is there an association with their earlier family situation?

By Simon Steiner, Dominik Schori and Gerhard Gmel− In existing literature on problematic substance use, parental influences such as parenting were often not examined in a uniform way and results are not consistent. This paper adds evidence for … [read more ...]

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Health, quality-of-life of patients admitted to inpatient rehabilitation before and after SwissDRG

By Argentina I. Stauber, Felix Angst, Judith Meier, et al. − The fixed-price tariff system SwissDRG was introduced into acute somatic health care in 2009 and is supposed to provide transparency and comparability, to improve efficiency and reduce … [read more ...]

CDC/ Dr. Ray Butler

Tuberculosis in a Swiss hospital

By Carlo Balmelli, Frédéric Zysset, Alberto Pagnamenta, et al. − Patients with smear-positive pulmonary tuberculosis may contaminate persons with whom they come in contact. This contact investigation in a hospital setting among HCW and patients … [read more ...]

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Vitamin D status among children and adolescents and anticonvulsant drugs

By Vera Ramelli, Gian Paolo Ramelli, Sebastiano A. G. Lava, et al. − There is a worldwide epidemic of hypovitaminosis D among children and adolescents. The present study indicates a relevant tendency towards hypovitaminosis D also among children … [read more ...]


Does an obesity paradox exist?

By Fabienne Witassek, Matthias Schwenkglenks, Paul Erne, Dragana Radovanovic − The observation that obese patients seem to have better outcomes than normal weight patients in a variety of disease conditions is known as “the obesity paradox”. … [read more ...]

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