Review articles

© Suemack |

Biological agents in monotherapy for the treatment of rheumatoid arthritis

Rheumatoid arthritis is one of the most frequently occurring autoimmune rheumatic diseases, affecting an estimated 1% of the global population. The synthetic disease-modifying antirheumatic drug (sDMARD) methotrexate (MTX) is a central agent in the … [read more ...]

© Ivan Cholakov |

Transcatheter renal denervation for the treatment of resistant arterial hypertension

Radiofrequency-based transcatheter (or percutaneous) renal denervation is a novel technique developed for treatment of hypertension. So far, one randomised trial has shown efficacy in reducing blood pressure. Because there are potential concerns … [read more ...]


Cochlear implantation in children and adults in Switzerland

The cochlear implant (CI) is one of the most successful neural prostheses developed to date. It offers artificial hearing to individuals with profound sensorineural hearing loss and with insufficient benefit from conventional hearing aids. In … [read more ...]

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Current opinion


Nuclear power plants and childhood leukaemia

In the 1980s, leukaemia clusters were discovered around nuclear fuel reprocessing plants in Sellafield and Dounreay in the United Kingdom. This raised public concern about the risk of childhood leukaemia near nuclear power plants (NPPs). Since then, … [read more...]

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Medical intelligence


Human hantavirus infections

It is currently estimated that, worldwide, 150,000 to 200,000 cases of hantavirus disease occur each year. The majority of these cases are reported in Asia, but the numbers of reports in the Americas and Europe are increasing. This review summarises … [read more ...]

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Original articles

© Alexander Lechler |

Prevalence and risk factors of late presentation for HIV diagnosis and care in a tertiary referral centre in Switzerland

The percentage of persons presenting late in our study was less than in recent reports from other countries. Nevertheless, the frequency of late testing could be ­further reduced by promoting awareness, particularly among older individuals and … [read more ...]

© Barbara Helgason |

Depression in early adulthood

Although depression in adults is known to be highly prevalent, and accounts for one of the leading causes of disease burden and decreased work productivity worldwide, little is known about depression prevalence in early adulthood. This study fills … [read more ...]


Non-neurological, steroid-related adverse events in very low birth weight infants

The use of systemic steroids – most importantly dexamethasone – in very low birth weight infants is discouraged because of severe neurological adverse events, although hydrocortisone has become more common, but systematic studies investigating … [read more ...]

© Johan Humblet |;

Observed costs and health care use of children in a prospective cohort study on community-acquired pneumonia in ­Geneva, Switzerland

There have been a number of efforts in estimating cost-effectiveness for introduction of pneumococcal conjugate vaccines. However, especially in Europe, very few reports on the cost burden of childhood pneumonia exist. Consequently the majority of … [read more ...]


Is trauma in Switzerland any different?

Trauma is the leading cause of death worldwide for ­patients under 44 years. Switzerland lacks data on incidence and outcome of severely injured patients, a key component of system planning for optimised efficiency and quality of trauma care. Trauma … [read more ...]


Opioid maintenance therapy in Switzerland

IMPROVE addressed many knowledge gaps in the field of addiction medicine, including treatment satisfaction, unmet needs, misuse and diversion, and common barriers to therapy. Study results represent a valuable ­resource for policy makers, key … [read more ...]

© Sudok1,

Prognostic value of nucleated red blood cells in critically ill children

  In critically ill adult patients, the presence of NRBCs is a strong predictor of mortality and NRBCs may be considered as a parameter that sums up hypoxic and inflammatory injuries. There are no studies on the prognostic value of NRBC in the … [read more ...]

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