Medical intelligence


PCSK9 inhibitors

By Baris Gencer, et al. − Proprotein convertase subtilisin kexin 9 (PCSK9) is a promising target in the management of lipid disorders. PCSK9 inhibition offers a novel therapeutic mechanism for the lowering of low-density lipoprotein cholesterol … [read more ...]


Promoting apoptosis of neutrophils and phagocytosis by macrophages: novel strategies in the resolution of inflammation

By Katherine R. Martin, et al. − Neutrophils play an essential role in the acute phase of inflammation. They can promote resolution, but  are also loaded with extremely powerful molecules. Therefore a key to mounting an effective immune response … [read more ...]

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Review articles

© Viktor Levi |;

Kidney paired donation: a plea for a Swiss National Programme

By Karine Hadaya et al. - Living donor kidney transplantation is associated with superior long-term recipient and graft survival compared with transplantation of kidneys from deceased donors. The global shortage of deceased donor organs has led to … [read more ...]


Current status and updated recommendations for diagnosis and treatment of plasma cell myeloma in Switzerland

By Panagiotis Samaras, et al. − The availability of drugs such as thalidomide, bortezomib and lenalidomide changed the landscape in myeloma treatment and has extended the median survival up to 10 years with a substantial improvement in quality of … [read more ...]

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© Birckoff |

Authoring scientific papers: a perspective from the trenches

By Adriano Aguzzi − It has taken a while, but the Swiss Academies of Arts and Sciences (SAAS) have come out with a valuable booklet on authorships of scientific manuscripts. This recommendations, published now also as a special article in the Swiss Medical Weekly, aspire to serve as a practical guide for principal investigators confronted […]

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Current opinion

© Giordano Aita |

Smarter medicine: do physicians need political pressure to eliminate useless interventions?

By Jean-Michel Gaspoz − In May 2014, the Swiss Society of General Internal Medicine launched a public campaign named “smarter medicine”. It listed five tests or treatments that may not provide any meaningful benefit for at least some ­patients … [read more...]


Only conflicts of interest?

By Reto Obrist − Public trust in science is being eroded by a growing awareness that scientific results, including those of clinical research, are very often false – they cannot be reproduced. Among the reasons for this is the bias introduced by … [read more...]

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Original articles

© Studiosnowden |;

Emergency department visits for non-life-threatening conditions

By Léonard Diserens, et al. − In many western countries, patients who need acute unscheduled care for non-life-threatening conditions consult more and more frequently an Emergency Departmentinstead of their general practitioner, contributing to … [read more ...]

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Increasing interventions for nursing home residents

By Carron PN, et al. − In the ageing European population, the proportion of interventions by EMS for elderly patients is increasing, but little is known about the recent trend of EMS interventions in nursing homes. This study revealed an important, … [read more ...]

© Mary Katherine Wynn |;

“An unspoken world of unspoken things”: Core beliefs underlying self-stigma among people living with HIV

By Nadine Ferris France, et al. − By HIV self-stigma includes negative self-judgements such as shame, self-blame and worthlessness. These negatively influence access to care and fulfilment of life goals among PLHIV, and are experienced to a greater … [read more ...]

© Fotoluminate,

Diagnosis in the emergency department

By Arno Peng, et al. − To our knowledge, this is the first prospective study that analysed the proportion of correct emergency department diagnoses in patients with nonspecific complaints.  … [read more ...]

© Picsfive,;

Insulin glargine in patients with type 2 diabetes

By Daniela Riebenfeld, et al. − Improvement of glycaemic control by means of basal insulin administration has been demonstrated in many studies. Real-life data, however, are rare and are not available for Swiss patients treated by general … [read more ...]

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Accuracy of doctors’ anthropometric measurements in general practice

By Paul Sebo, et al. − Recent findings from a study involving GPs working in an academic primary care clinic showed that the newer measurement methods were unreliable for identifying obesity. Our findings confirm that the classical anthropometric … [read more ...]


Post-treatment surveillance of head and neck cancer: pitfalls in the interpretation of FDG PET-CT/MRI

By Christian Martin Meerwein, et al. − FDG PET-CT has become a valuable tool in post-treatment surveillance. However, there are various non-malignant FDG-positive conditions, which may cause increased FDG uptake. The aim of this study was to … [read more ...]

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