Review articles

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The advent of biosimilars: challenges and risks

Biosimilars represent a new class of medicinal products that will have significant impact on clinical use. They are identical on a amino acid sequence level to existing reference biopharmaceutical products. However, they may exhibit differences on a … [read more ...]

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The role of teriparatide in sequential and combination therapy of osteoporosis

Treatment of osteoporosis with antiresorptive agents cannot fully and rapidly restore bone mass and structure that has been lost because of increased remodelling. However, recombinant human parathyroid analogues, such teriparatide, do increase the … [read more ...]

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Medical intelligence

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Circadian rhythms – from genes to physiology and disease

By Thomas Bollinger and Ueli Schibler − In this review article the authors give an overview on the molecular and cellular architecture of the mammalian circadian timing system and provide some thoughts on its medical and social impact. … [read more ...]

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Current opinion

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Bisphosphonate induced hypocalcaemia

Intravenous bisphosphonates are widely used to treat osteoporosis and bone metastasis in cancer patients. The risk of hypocalcaemia is a rare but underestimated side effect of anti-resorptive treatment. Clinically apparent hypocalcaemia is mostly … [read more...]

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Original articles

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Why did Swiss citizens refuse a comprehensive ­second-hand smoke ban?

By André-Dante Durham, Pascal Diethelm and Jacques Cornuz − Switzerland  has only a partial smoking ban full of exceptions which  has been in effect since 2010. This case study examines the reasons behind this rejection and draws some lessons … [read more ...]

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Utility of a single cortisol value after ACTH-stimulation

By Thomas Zueger, Marlen Jordi, Markus Laimer and Christoph Stettler – The high dose ACTH stimulation test (HDT) is frequently used in the assessment of AI but there is uncertainty regarding the requested time-points and number of blood … [read more ...]

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Efficacy of anti-fungal but not anti-bacterial prophylaxis in intensive primary AML therapy

By Bernhard Gerber, Jan Köppel, Michaela Paul et al. – The data on the efficacy of posaconazole in the prophylaxis setting is in line with prior reports, but the inclusion of patients with possible invasive fungal infections adds relevant new … [read more ...]

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Cognitive and emotional effects of carotid stenosis

Patients with CAS often show decreased cognitive performance and increased anxiety level. Bilateral and symptomatic stenosis is associated with slower processing speed. Factors associated with less cognitive impairment included higher education … [read more ...]

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Length of stay, patients’ outcome and satisfaction in ­Switzerland before and after SwissDRG implementation

What is known: On 1 January 2012 a new uniform case-based payment system for inpatients (SwissDRG) was introduced in Switzerland. What this paper adds: Mean LOS in the overall patient population was comparable between the 2011 cohort and the 2012 … [read more ...]

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Reduction in the use of diagnostic tests in infants with risk factors for early-onset neonatal sepsis does not delay anti­biotic treatment

Diagnostic tests are commonly used to evaluate whether antibiotics should be started in infants at risk for early-onset neonatal sepsis. This study indicates that infants with neonatal infection can be identified early by means of clinical … [read more ...]

questionnaire

Function and activity in patients with knee arthroplasty: validity and reliability of a German version of the Lysholm Score and the Tegner Activity Scale

The Lysholm score and the Tegner activity scale are widely used for assessing knee function and activity level after knee ligament injuries. This paper adds that those questionnaires can also be used in patients with a total knee arthroplasty. … [read more ...]

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