Medical intelligence

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Eroding students’ rural motivation: first do no harm?

By Samia A. Hurst − In the global scarcity of medical professionals, the clearest deficits of physicians exist precisely in the areas of the world where the need for them is greatest. Rather than only representing a missed opportunity for improving … [read more ...]


Toxic oligomer species of amyloid-β in Alzheimer’s disease, a timing issue

By Sylvain E. Lesne − Alzheimer’s disease is characterised by the presence of amyloid plaques and neurofibrillary tangles in postmortem human brain tissue. These lesions are respectively formed of insoluble fibrillar species of the amyloid-β … [read more ...]

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Current opinion

Photo: © Sudok1 |

Interventional treatment for structural heart disease: who is deciding, and can we afford it?

By Raban V. Jeger and Stefan Toggweiler − During the last years, the numbers of interventions in structural heart disease such as transcatheter aortic valve implantation (TAVI), percutaneous treatment of mitral regurgitation using the MitraClip, … [read more...]

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"Human neutrophil ingesting MRSA" by National Institutes of Health (NIH) - National Institutes of Health (NIH). Licensed under Public domain via Wikimedia Commons

Abnormal flora and infection in critically ill patients

By Peter H.J. van der Voort − All critically ill patients go through a period of inflammatory response as they suffer from tissue injury caused by infection, trauma, surgical procedure, pancreatitis, ischaemia or burn. The inflammation can be measured by high levels of pro-inflammatory cytokines (e.g., IL-6, TNF-α) and the hyper metabolic state. A paradox […]

Review articles

© Sebastian Kaulitzki |;

The painful primary hip replacement

By Csaba Forster-Horvath, Christian Egloff, Victor Valderrabano, Andrej M. Nowakowski − Patient satisfaction after total hip replacement is ­reported to be high, but subsequent chronic pain may be problematic. The rate of revision procedures due … [read more ...]

«Human neutrophil ingesting MRSA» by National Institutes of Health (NIH) – National Institutes of Health (NIH). ­Licensed ­under Public domain via Wikimedia Commons.

Enterococci, Clostridium difficile and ESBL-producing bacteria: ­epidemiology, clinical impact and prevention in ICU patients

By Jan A. Sidler, Manuel Battegay, Sarah Tschudin-Sutter, Andreas F. Widmer and Maja Weisser − Most hospital-acquired infections arise from colonising bacteria. Intensive care patients and immunocompromised individuals are at highest risk for … [read more ...]

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Original articles

Heart allocation and transplantation in Switzerland since the introduction of the Swiss Organ Allocation System

By Julius Weiss, Franziska Beyeler, Franz F. Immer, Swisstransplant Heart Working Group (STAH) − Switzerland is faced with an increasing number of patients waitlisted for a heart transplant. Compared with international data, the acceptance rate of … [read more ...]


Swiss monitoring of potential organ donors

By Julius H. Weiss, Isabelle Keel, Franz F. Immer, Jan Wiegand, Christoph Haberthür and the Comité National du Don d’Organes − Switzerland has one of the lowest post mortem organ donation rates in Europe. The main reason is the high number of … [read more ...]

© Ivan Cholakov |

Early detection of subjects at risk for vascular remodelling

By Julia Dratva, Seraina Caviezel, Emmanuel Schaffner et al. − We present first Swiss data on CIMT from a population-based study. Analyses confirm the longitudinal impact of CVD risk factors on vessel health, and the predictive power of the risk … [read more ...]

Photo: © Mykhaylo Palinchak |

Cyclophosphamide: As bad as its reputation?

By Diana Dan, Rahel Fischer, Sabine Adler, Frauke Förger, Peter M. Villiger − The negative image of cyclophosphamide regarding its side effects stems from its use in oncology and long-term per os medication with high cumulative doses. Very few … [read more ...]


Butorphanol pre-treatment prevents myoclonus induced by etomidate

By He L, Ding Y, Chen H, Qian Y, Li Z − Some opioids can decrease etomidate-induced myoclonics, but with the cost of clinically distressing side effects. … [read more ...]

© Gabriel Blaj |

Medical decision-making capacity

By Helena Hermann, Manuel Trachsel, Christine Mitchell and Nikola Biller-Andorno − The conceptual and practical challenges of decision-making capacity are far from being resolved. There is a clear need for more guidance in this area in the form of … [read more ...]


Outcome of extremely low gestational age newborns following a pro-active treatment approach

By Davide Morgillo, et al. − Major advances in perinatal care have led to significantly improved survival rates of extremely low gestational age neonates (gestational age <28 weeks) over the last three decades. Concerns have been raised whether … [read more ...]

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