Current opinion

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The role of clinical trial units in patient-based research

By Belinda von Niederhäusern, Thomas Fabbro and Christiane Pauli-Magnus − Clinical Trial Units (CTUs) act as interdisciplinary competence centres for clinical research at their local – and surrounding – academic institutions. In spite of … [read more...]

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Aetiological blood biomarkers of ischaemic stroke

By Julian Sonderer and  Mira Katan Kahles − Stroke tends to be a much more heterogeneous condition than ischaemic heart disease. Causes of stroke include small and large vessel disease, cardioembolism, dissections, and rare vasculo- and … [read more...]

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Medical intelligence

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PCSK9 inhibitors

By Baris Gencer, et al. − Proprotein convertase subtilisin kexin 9 (PCSK9) is a promising target in the management of lipid disorders. PCSK9 inhibition offers a novel therapeutic mechanism for the lowering of low-density lipoprotein cholesterol … [read more ...]

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Editorial

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Left ventricular thrombus ­formation after AMI

Left ventricular thrombus formation is a feared complication following acute myocardial infarction, predominantly owing to the risk of thromboembolism, in particular, stroke.

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Review articles

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Sudden cardiac death in forensic medicine

By Matthias Wilhelm, et al. − Cases of sudden cardiac death, particularly in younger people, may have important implications for the family of the deceased. Extensive histopathological investigations and/or molecular genetic analyses are necessary … [read more ...]

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Acute painful diabetic neuropathy

By Christel Tran, et al. − Peripheral neuropathies are well-known complications of diabetes. Acute painful diabetic neuropathy (APDN), one of the less common types, is associated with the rapid decrease of high glycaemic levels. This article … [read more ...]

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Original articles

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Patients with an extraordinarily ­el­e­vated serum ferritin

By Marc Schweizer, Jeroen S. Goede and Verena Briner − Haemophagocytic lympho­cytosis has been described in association with various causes. Almost all of our HLH patients suffered from a ­haematological or oncological malignancy and had a bad … [read more ...]

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Time-trends in assisted and ­unassisted completed suicides

By Nicole Steck, et al. − The number of suicides assisted by right-to-die associations has increased in recent years in Switzerland. We showed that this led to an increase in rates of suicide in women in recent years. … [read more ...]

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Thrombus formation in the left ventricle after large AMI – assessment with cardiac magnetic resonance imaging

By Daniel Sürder, et al. − Occurrence of left ventricle thrombi was comparable to other studies. Left ventricle thrombi might be missed if transthoracic echocardiography (TTE) or cine-CMR without contrast are used as diagnostic techniques, so … [read more ...]

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