Review articles


PCSK9 inhibitors and statin ­intolerance

Statins are the most widely prescribed class of drugs worldwide and are generally safe and well tolerated; however, statin intolerance is not uncommon in real-world practice. Patients who are at high cardiovascular risk but cannot achieve low-density … [read more...]


Leg ­ischaemia in ECLS and ECMO with peripheral cannulation

By Ludwig K. von Segesser, et al.: In respiratory failure, extracorporeal membrane oxygenation provides ­extrapulmonary gas transfer for both O2 and CO2, and can usually be established via peripheral venous cannulation. For assisting the failing … [read more...]


Advanced ECG in 2016: is there more than just a tracing?

By Tobias Reichlin, et al.: Remarkable progress in biomedical computing, signal processing and computational power has generated novel ECG markers and technologies. These offer new opportunities to address current unmet needs in clinical cardiology. … [read more...]

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Comorbidity in rheumatoid arthritis

By Carl Turesson: Rheumatoid arthritis (RA) is associated with increased mortality compared with the general population, mainly due to other coexisting diseases, such as cardiovascular disease and infections. There has been major progress in the … [read more...]


Mechanisms of protein homeo­stasis in health, aging and disease

By Pierre Goloubinoff: Aging is a natural and necessary degenerative process of the somatic cells, leading to death. Young embryonic, germline and cancer cells are potentially immortal by virtue of their ability to massively produce optimal defences … [read more...]

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Original articles


Somatisation and anger associated with symptom severity of PTSD

By Tobias R. Spiller, et al.: The numbers of refugees in Europe and worldwide have dramatically increased. Most research on refugee mental health has focused on posttraumatic stress disorder. Besides PTSD, however, traumatised refugees are often … [read more ...]


Systematic screening for Lynch syndrome in colorectal cancer

By Valentin Zumstein, et al.: Germline mutations in DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2 cause autosomal dominantly inherited Lynch syndrome. Lynch syndrome patients and their families benefit from life-saving intensive cancer … [read more ...]


Prevalence and determinants of chronic kidney disease

By Valentina Forni Ogna, et al.: The prevalence of chronic kidney disease (CKD) is increasing worldwide, corresponding to an increased risk of cardiovascular disease. The latest study on prevalence of CKD involving the three linguistic regions of … [read more ...]


Parents’ and patients’ experiences with paediatric oncology care

By Tenzin Wangmo, et al.: This paper explores parents’ and patients’ satisfaction with care in Swiss paediatric oncology settings and examines difficulties experienced while undergoing treatment for cancer. … [read more ...]

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